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Update on pathophysiology and preventive strategies of anthracycline‐induced cardiotoxicity
Author(s) -
Corremans Raphaëlle,
Adão Rui,
De Keulenaer Gilles W.,
LeiteMoreira Adelino F.,
BrásSilva Carmen
Publication year - 2019
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13036
Subject(s) - cardiotoxicity , anthracycline , medicine , doxorubicin , intensive care medicine , cardiomyopathy , cancer , chemotherapy , heart failure , bioinformatics , pharmacology , breast cancer , biology
Summary Anthracycline chemotherapy has a prominent role in treating many forms of cancer. Unfortunately, cardiotoxic side effects represent a serious limitation to their use, with doxorubicin being the leading drug of the group. Indeed, anthracycline‐induced cardiomyopathy is an important public health concern because it may not be detected for many years and remains a lifelong threat. Even after decades of investigation, neither the exact mode of action of anthracyclines nor the pathways leading to their side effect are fully understood. It is increasingly important to establish collaboration between oncologists and cardiologists to improve the management of cancer patient receiving anthracyclines. This article reviews the clinical course, pathogenesis, cardiac monitoring and new concepts in diagnosing and preventing anthracycline‐induced cardiotoxicity.