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Non‐invasive three‐dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage
Author(s) -
Yamamoto Shuzo,
Mutoh Tatsushi,
Sasaki Kazumasu,
Mutoh Tomoko,
Tatewaki Yasuko,
Taki Yasuyuki
Publication year - 2019
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13035
Subject(s) - subarachnoid haemorrhage , cerebral blood flow , medicine , power doppler , subarachnoid hemorrhage , blood flow , radiology , doppler effect , cardiology , ultrasonography , physics , aneurysm , astronomy
Summary We aimed to evaluate the feasibility of a non‐invasive method of cerebral blood flow (CBF) measurement using high‐frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3‐dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow ( r 2 = 0.52, P < 0.0001) and normalized CBF changes ( r 2 = 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real‐time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.