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Function of AT1 and AT2 receptors in atrial contractions from spontaneous hypertensive and diabetic‐induced streptozotocin rats
Author(s) -
Musial Diego Castro,
MirandaFerreira Regiane,
Padin Juan Fernando,
ArranzTagarro Juan Alberto,
ParraVitela Alberto J.,
Jurkiewicz Aron,
Garcia Antonio Garcia,
Jurkiewicz Neide Hyppolito
Publication year - 2018
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13019
Subject(s) - medicine , endocrinology , losartan , angiotensin ii receptor type 1 , streptozotocin , renin–angiotensin system , angiotensin ii , diabetes mellitus , blood pressure , receptor
Summary Diabetes mellitus and hypertension are diseases that are strongly correlated. A major factor in this correlation is the renin–angiotensin system ( RAS ), with the peptide angiotensin II being a key component. This study analyzed the impact of Angiotensin Type 1 receptor ( AT 1R) and Angiotension Type 2 receptor ( AT 2R) in atrial function. Main methods To perform the experiments, Wistar Kyoto rats ( WKY ), diabetic streptozotocin‐induced WKY rats and spontaneously hypertensive rats ( SHR ) were used, and stimulation of cardiovascular function was done by means of the following drugs: angiotensin II , novokinin and the antagonists losartan and PD 123177. We also measured the systolic blood pressure ( SBP ). Results An increase in AT 1R function was observed in diabetic and hypertensive rats (18% in right atria [ RA ] and 11% in left atria [ LA ]). We also observed an increase in calcium release from the endoplasmic reticulum in right atria of diabetic rats (31%) and in right atria of hypertensive rats (35%). On the other hand, a decreased response of AT 2R in diabetic and hypertensive rats was observed, this decreased response was greater in hypertensive rats ( RA , 10%; LA , 12%). These results have demonstrated a dysfunction of the RAS that may contribute to the common dysfunctions of the cardiovascular system in diabetic and hypertensive rats.