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Relationships between meconium concentrations of acute phase proteins
Author(s) -
LisowskaMyjak Barbara,
Skarżyńska Ewa,
Płazińska Maria,
Jakimiuk Artur
Publication year - 2018
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12995
Subject(s) - meconium , lipocalin , lactoferrin , neutrophil gelatinase associated lipocalin , acute phase protein , medicine , fetus , ceruloplasmin , endocrinology , chemistry , andrology , biology , biochemistry , pregnancy , inflammation , genetics
Summary Meconium concentrations of naturally accumulated ceruloplasmin (CER), lactoferrin (LF), and neutrophil gelatinase‐associated lipocalin (NGAL) and their relationships considered as a panel of acute phase proteins could be used for the assessment of fetal homeostasis. CER, LF and NGAL concentrations were measured using enzyme‐linked immunosorbent assay kits in meconium portions (n = 80) collected from 19 healthy neonates. The coefficients of variation (CV) of the meconium LF (1.77) and NGAL (1.26) were about two‐fold higher than that of CER (0.73) with significant ( P < 0.05) correlations between all three parameters. The LF to NGAL ratio (CV = 0.67) correlated strongly with the CER concentrations ( r = 0.39, P < 0.01). These correlations between CER, LF and NGAL concentrations suggest their combined involvement in the metabolic processes in the developing fetus.