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Identification and evaluation of 2 circulating micro RNA s for non‐small cell lung cancer diagnosis
Author(s) -
Wang Xiaoqin,
Jia Zhongzhi,
Shi Haifeng,
Pan Changjie
Publication year - 2018
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12977
Subject(s) - lung cancer , microrna , medicine , clinical diagnosis , cancer , oncology , gene , biology , clinical psychology , biochemistry
Summary The circulating mi RNA s are dysregulated in non‐small cell lung cancer ( NSCLC ) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum mi RNA s for NSCLC diagnosis. We found that miR‐21 and let‐7a were significantly dysregulated in NSCLC patients ( P < .001). When applied for NSCLC diagnosis, combined application of miR‐21 and let‐7a had a sensitivity of 0.790, specificity of 0.750, which is significantly higher than application alone of miR‐21(sensitivity 0.647; specificity 0.641), let‐7a (sensitivity 0.653; specificity 0.718) or computed tomography‐guided core‐needle biopsy ( CTCB ) (sensitivity 0.725; specificity 0.609) ( P < .01). In conclusion, our study indicates that combined application of circulating miR‐21 and let‐7a has advantages over traditional CTCB technique.