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Association between UDP ‐glucuronosyltransferase 2B7 tag SNP s and breast cancer risk in Chinese females
Author(s) -
He BaoXia,
Qiao Bin,
Lam Alfred KingYin,
Zhao XiuLi,
Zhang WenZhou,
Liu Hui
Publication year - 2018
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12908
Subject(s) - breast cancer , genotype , single nucleotide polymorphism , allele , medicine , haplotype , oncology , odds ratio , snp , cancer , endocrinology , biology , genetics , gene
Summary This retrospective study was performed to evaluate the association between the UGT 2B7 tag SNP s (rs12233719, rs4356975, rs7435335 and rs7441774) and breast cancer in Chinese females. Blood samples were collected from 672 patients with breast cancer and 670 healthy controls for DNA extraction. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry ( MALDI ‐ TOF MS ) was used to analyze UGT 2B7 polymorphisms. Dual‐luciferase reporter assays were further performed to investigate the regulatory function of UGT 2B7 tag SNP s. The frequency of rs7441774 G allele in the breast cancer cases was statistically significantly higher than in the controls (0.412 vs 0.358, P = .006; odds ratio [ OR ] = 1.27, 95% CI = 1.08‐1.48). After adjusting for conventional risk factors, individuals with the GG genotype had a higher breast cancer risk than those with the AA genotype (adjusted OR = 1.63, 95% CI = 1.18‐2.26; P = .008). The GCGG haplotype of UGT 2B7 was also associated with breast cancer ( OR = 1.22, 95% CI = 1.04‐1.45; P = .027). Meanwhile, the rs7441774 G allele could significantly decrease the transcriptional activity of the UGT 2B7 gene. This study indicates that UGT 2B7 polymorphisms may play a crucial role in the occurrence and development of breast cancer in the Han Chinese population.