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Relationship between urinary sodium‐to‐potassium ratio and ambulatory blood pressure in patients with diabetes mellitus
Author(s) -
Libianto Renata,
Moran John,
O'Callaghan Christopher,
Baqar Sara,
Chen Angela X,
Baker Scott T,
Clarke Michelle,
MacIsaac Richard J,
Jerums George,
Ekinci Elif I
Publication year - 2018
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12852
Subject(s) - blood pressure , sodium , medicine , ambulatory blood pressure , diabetes mellitus , potassium , urinary system , ambulatory , endocrinology , urology , chemistry , organic chemistry
Summary Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross‐sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium‐to‐potassium ratio ( R 2 = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium‐to‐potassium ratio and dipping status.