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Long non‐coding RNA s in aging organs and tissues
Author(s) -
Xing Wenmin,
Gao Wenyan,
Mao Genxiang,
Zhang Jing,
Lv Xiaoling,
Wang Guofu,
Yan Jing
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12795
Subject(s) - biology , long non coding rna , microrna , cellular aging , rna , computational biology , microbiology and biotechnology , genetics , telomere , gene
Summary The aging process directly impacts bodily functions on multiple levels, including a reduced ability to resist stress, damage and disease. Besides changes in metabolic control, the aging process coincides with the altered long non‐coding RNA s (lnc RNA s) expression, which are ≥200nt long class of non‐protein coding RNA s. The majority of non‐coding transcripts of mammalian organs and tissues are expressed in developmentally regulated and cell‐type specific manners. Specific altered lnc RNA level has been involved in induction and maintenance of the whole human body aging with highly specific spatial andtemporal expression patterns. Furthermore, many lnc RNA s are transcribed in sense, antisense and bidirectional manners in the mammalian genome. They play a vital role in regulating organ or tissue differentiation during aging by binding with mi RNA or proteins to act as a decoy. Recently, the correlation between lnc RNA s and aging has been studied intensely. Here, we have summarized some examples of known and novel lnc RNA s that have been implicated in the aging process in the whole mammalian body and we discuss these patterns, conservation and characters during aging. This may further promote the development of research on lnc RNA s and the aging process.