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Oncogenic role of neurotensin and neurotensin receptors in various cancers
Author(s) -
Ouyang Qing,
Zhou Ji,
Yang Wei,
Cui Hongjuan,
Xu Minhui,
Yi Liang
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12787
Subject(s) - paracrine signalling , autocrine signalling , neurotensin , biology , neurotensin receptor , receptor , cancer research , kinase , cancer , cancer cell , cell growth , microbiology and biotechnology , neuropeptide , genetics
Summary Neurotensin ( NTS ) has long been recognized as a neurotransmitter or neuromodulator in the central nervous system and as an endocrine agent in the periphery via actions mediated through neurotensin receptors ( NTSR s). Many studies support a role for NTS in the endocrine, autocrine and paracrine growth stimulation of cancer, with oncogenic actions described for NTS in different types of cancers and cancer cell lines at each step of cancer progression, ranging from tumour growth and survival to metastatic spread. The mechanisms underlying the effects of the NTS / NTSR system in cell proliferation, migration and invasion, as well as the anti‐apoptotic effects of this system, have been elucidated in different types of cancers, and include mitogen‐activated protein kinases, phosphatidylinositol 3‐kinase and Rho GTP ases. The present mini review summarizes recent findings relating to the oncogenic function of the NTS / NTSR system.