Premium
Micro RNA regulation of extracellular matrix components in the process of atherosclerotic plaque destabilization
Author(s) -
Kowara Michal,
CudnochJedrzejewska Agnieszka,
Opolski Grzegorz,
Wlodarski Pawel
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12772
Subject(s) - extracellular matrix , proteases , elastin , microbiology and biotechnology , matrix metalloproteinase , microrna , chemistry , cathepsin , extracellular , biology , biochemistry , enzyme , gene , genetics
Summary The process of atherosclerotic plaque destabilization, leading to myocardial infarction, is still not fully understood. The pathway – composed of structural and regulatory proteins of the extracellular matrix ( ECM ) such as collagen, elastin, small leucine‐rich proteoglycans, metalloproteinases, cathepsins and serine proteases – is one potential way of atherosclerotic plaque destabilization. The expression of these proteins is controlled by different micro RNA molecules. The goal of this paper is to summarize the current investigations and knowledge about ECM in the process of atherosclerotic plaque destabilization, giving special attention to epigenetic expression regulation by micro RNA .