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Amplification of FSH signalling by CFTR and nuclear soluble adenylyl cyclase in the ovary
Author(s) -
Chen Hui,
Chan Hsiao Chang
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12756
Subject(s) - adenylyl cyclase , camp dependent pathway , microbiology and biotechnology , signal transduction , cystic fibrosis transmembrane conductance regulator , protein kinase a , chemistry , adcy10 , gs alpha subunit , receptor , biology , kinase , biochemistry , gene
Summary The cAMP / PKA pathway is one of the most important signalling pathways widely distributed in most eukaryotic cells. The activation of the canonical cAMP / PKA pathway depends on transmembrane adenylyl cyclase (tm AC ). Recently, soluble adenylyl cyclase ( sAC ), which is activated by HCO 3 − or Ca 2+ , emerges to provide an alternative way to activate cAMP / PKA pathway with the cystic fibrosis transmembrane conductance regulator ( CFTR ), a cAMP ‐activated Cl − / HCO 3 − ‐conducting anion channel, as a key player. This review summarizes new progress in the investigation of the CFTR / HCO 3 − ‐dependent sAC signalling and its essential role in various reproductive processes, particularly in ovarian functions. We present the evidence for a CFTR / HCO 3 − ‐dependent nuclear sAC signalling cascade that amplifies the FSH ‐stimulated cAMP / PKA pathway, traditionally thought to involve tm AC , in granulosa for the regulation of oestrogen production and granulosa cell proliferation. The implication of the CFTR / HCO 3 − / sAC pathway in amplifying other receptor‐activated cAMP / PKA signalling in a wide variety of cell types and pathophysiological processes, including aging, is also discussed.