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Gastric cancer management: Kinases as a target therapy
Author(s) -
Farran Batoul,
Müller Susanne,
Montenegro Raquel C
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12743
Subject(s) - cancer , trastuzumab , medicine , kinase , targeted therapy , epidermal growth factor receptor , cancer research , epigenetics , pi3k/akt/mtor pathway , clinical trial , bioinformatics , oncology , biology , signal transduction , breast cancer , genetics , gene
Summary The molecular diagnostics revolution has reshaped the practice of oncology by facilitating the identification of genetic, epigenetic and proteomic modifications correlated with cancer, thus delineating ‘oncomaps’ for various cancer types. These advances have enhanced our understanding of gastric cancer, one of the most fatal diseases worldwide, and culminated in the approval of novel molecular therapies such as trastuzumab. Gastric tumours display recurrent aberrations in key kinase oncogenes such as Her2, epidermal growth factor receptor ( EGFR ), PI 3K, mTOR or c‐Met, suggesting that these receptors are amenable to inhibition using specific drug agents. In this review, we examine the mutational landscape of gastric cancer, the use of kinase inhibitors as targeted therapies in gastric tumours and the clinical trials underway for novel inhibitors, highlighting successes, failures and future directions.