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Impact of polymorphisms in angiogenesis‐related genes on clinical outcomes of radiotherapy in patients with nasopharyngeal carcinoma
Author(s) -
Ma WanLe,
Liu Rong,
Huang LiHua,
Zou Chan,
Huang Jie,
Wang Jing,
Chen ShaoJun,
Meng XiangGuang,
Yang JingKe,
Li Han,
Yang GuoPing,
Guo ChengXian
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12738
Subject(s) - nasopharyngeal carcinoma , mucositis , oncology , medicine , radiation therapy , logistic regression , angiogenesis , genotype , snp , gene , single nucleotide polymorphism , biology , genetics
Summary The purpose of this paper is to assess the relationship between gene polymorphism in angiogenesis‐related genes and radiation responses in nasopharyngeal carcinoma ( NPC ) patients. The genotypes of 180 NPC patients were analyzed by Sequenom Mass ARRAY . The response evaluation criteria in solid tumours were used for assessing efficacies, and the criteria of the Radiation Therapy Oncology Group or European Organization for Research & Treatment of Cancer were utilized for evaluating acute toxic reactions in response to radiation. Statistical methods included chi‐square test, uni‐ and multivariate logistic regression analyses. Genotypic carriers of rs1800541 GT were at an elevated risk of developing grade 3+ oral mucositis, and a genetic variant of rs5333 was a predictor for a lower occurring risk of grade 2+ radiation‐induced xerostomia. EDN 1 rs1800541, rs2071942 and rs5370 variants were associated with a significantly higher risk of severe myelosuppression. SNP s in such angiogenesis‐related genes as EDN 1 rs1800541, rs2071942 & rs5370 and EDNRA rs5333 may serve as useful biomarkers for predicting the outcomes of NPC patients.