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Decreased percentage of NKG 2D+ NK cells in patients with incident onset of Type 1 Diabetes
Author(s) -
Zhang Yupan,
Wang Haifeng,
Lou Xiaoqian,
Qu Xiaozhang,
Gao Lichao,
Liu Xiaolei,
Li Man,
Guo Hui,
Jiang Yanfang
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12699
Subject(s) - nkg2d , type 1 diabetes , flow cytometry , endocrinology , medicine , peripheral blood , diabetes mellitus , immunology , cd3 , natural killer cell , interleukin 21 , pathogenesis , biology , cd8 , immune system , cytotoxic t cell , in vitro , biochemistry
Summary Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency owing to autoimmune destruction of the pancreatic β cells. A significant decrease in natural killer (NK) cells in peripheral blood has been observed in patients with untreated T1DM. In the present study, we aimed to explore the role of NK cells and their subsets in young T1DM patients. A total of 30 children and adolescents with untreated T1DM and 27 healthy controls (HC) were recruited in this study. Flow cytometry analysis indicated that the percentage of peripheral blood CD3‐CD56+ NK cells and NK cells subsets (CD56bright, CD56dim and CD56neg), were significantly decreased in the T1DM patients compared to healthy controls. In addition, the percentage of inducible CD107a+ and IFN‐γ‐secreting NK cells was significantly decreased compared to HC. Interestingly, the percentage of NKG2D+ NK cells negatively correlated with the level of serum TCHOL and TG in T1DM patients. Our data indicate that decreased number and impaired function of NK cells may have a role in the pathogenesis of T1DM.