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Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians
Author(s) -
Abdel Rahman Mohamed F,
Hashad Ingy M,
AbouAisha Khaled,
Abdel Maksoud Sahar M,
Gad Mohamed Z
Publication year - 2017
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12684
Subject(s) - myocardial infarction , endothelin receptor , endothelin 1 , medicine , cardiology , receptor
Summary The aim of the current study was to assess the link between EDN K198N SNP , ET ‐1 serum concentration and acute myocardial infarction ( AMI ) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age‐matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA , respectively. Genotype distribution was not significantly different between AMI patients and controls ( P =.8341). The mean serum ET ‐1 concentration of patients (13.83±0.7 pg/ mL ) was significantly higher than controls (7.26±0.2 pg/ mL ) ( P <.0001). ET ‐1 serum concentrations did not vary significantly among various EDN genotypes in patients ( P =.378) and controls ( P =.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET ‐1 concentration or incidence of early‐onset AMI in Egyptians. But, AMI patients had higher ET ‐1 concentrations than controls.