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Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women
Author(s) -
Figueroa Arturo,
AlvarezAlvarado Stacey,
Jaime Salvador J,
Johnson Sarah A,
Campbell Jeremiah C,
Feresin Rafaela G,
Elam Marcus L,
Navaei Negin,
Pourafshar Shirin,
Arjmandi Bahram H
Publication year - 2016
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12655
Subject(s) - cardiology , pulse wave velocity , medicine , blood pressure , arterial stiffness , pulse pressure , aortic pressure , hemodynamics , peripheral , sarcopenia
Summary Sarcopenia, defined by reduced appendicular skeletal muscle mass ( ASM )/height 2 ( ASMI ), is associated with increased arterial stiffness (brachial‐ankle pulse wave velocity, ba PWV ) and wave reflection (augmentation index, AI x). Blood pressure ( BP ) responses to metaboreflex activation (post‐exercise muscle ischemia, PEMI ) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low‐ ASMI and normal‐ ASMI . Resting radial AI x and ba PWV as well as brachial and aortic systolic BP , pulse pressure, systolic time index, and subendocardial viability ratio ( SEVR ) responses to PEMI were greater in women with low‐ ASMI than normal‐ ASMI . Increased ba PWV associated with low‐ ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.