Premium
Blunted renal vasoconstriction in patients with subclinical contrast‐induced renal injury
Author(s) -
Kurihara Osamu,
Seino Yoshihiko,
Shibata Yusaku,
Matsushita Masato,
Komiyama Hidenori,
Kato Katsuhito,
Murakami Daisuke,
Munakata Ryo,
Takano Masamichi,
Miyauchi Yasushi,
Hata Noritake,
Shimizu Wataru
Publication year - 2016
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12653
Subject(s) - vasoconstriction , medicine , acute kidney injury , kidney , renal blood flow , vascular resistance , renal artery , renal circulation , renal injury , subclinical infection , hemodynamics , cardiology , urology
Summary Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver‐type fatty acid‐binding protein levels following contrast medium administration were compared between groups with or without a micro‐injury of the kidney. In the group without renal micro‐injury, the average peak velocity ( APV ) decreased significantly, whereas the renal artery resistance index ( RI ) increased significantly following contrast medium administration. In contrast, there was no significant change in either the APV or RI in the group with a renal micro‐injury. A blunted microvascular response was found in the micro‐injury group, whereas microvascular resistance increased in the non‐micro‐injury group.