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Increased serum GDF 11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women
Author(s) -
Jin Miaomiao,
Song Shumin,
Guo Lijuan,
Jiang Tiejian,
Lin ZhangYuan
Publication year - 2016
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12651
Subject(s) - osteoporosis , medicine , femoral neck , endocrinology , quartile , serum concentration , confidence interval
Summary Osteoporosis is an age‐related disease. Many studies have confirmed the anti‐aging effect of growth differentiation factor 11 ( GDF 11), but the action of GDF 11 on bone metabolism remains unclear. In this study, we aimed to investigate the relationship between serum GDF 11 levels and the prevalence of osteoporosis. Our data indicate negative correlations between serum GDF 11 levels and BMD at the lumbar spine and femoral neck. The serum GDF 11 levels were grouped into quartile intervals, and the prevalence and risk of osteoporosis were found be markedly greater with increased GDF 11 levels. This study demonstrated that GDF 11 was negatively correlated with BMD in elderly Chinese women. Furthermore, osteoporotic risk was significantly increased with increases in GDF 11 levels.