Premium
Multipotent bone marrow stromal cell therapy promotes endogenous cell proliferation following ischemic stroke
Author(s) -
Pirzad Jahromi Gila,
Shabanzadeh Pirsaraei Alireza,
Sadr Seyed Shahabeddin,
Kaka Golamreza,
Jafari Mahvash,
Seidi Sadegh,
Charish Jason
Publication year - 2015
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12466
Subject(s) - stromal cell , medicine , astrocytosis , stroke (engine) , bone marrow , endogeny , ischemia , neuroscience , pathology , central nervous system , biology , mechanical engineering , engineering
Summary Despite extensive research over the years, there still exists some debate as to what constitutes the optimal therapeutic strategy to promote recovery following stroke. Due to the complexity of injured brain pathophysiology, treatment approaches should ideally address numerous factors, ultimately aiming to promote tissue protection, axonal regrowth and functional recovery. This study extends the understanding of the effects of bone marrow stromal cell ( BMSC ) treatment following experimentally induced ischemic stroke in rats. Focal ischemic brain injury was experimentally induced in rats by placing a preformed clot into the middle cerebral artery. Animals were injected intravenously with BMSC s at 24 h after stroke and were killed 7 days post injury. When administered BMSC s following stroke, the neurological outcome was significantly improved relative to controls. There was an increase in the number of BMSC s labelled with BrdU present in the injured hemisphere of the brain compared to the non‐injured side. Furthermore, administration of BMSC s also led to increases in astrocytosis, vascularization and endogenous proliferation. These findings provide insight into the mechanisms of action of BMSC treatment and further argue for the therapeutic potential of BMSC s as an effective treatment following cerebral stroke.