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Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation
Author(s) -
Hamad Rania,
Jayakumar Calpurnia,
Ranganathan Punithavathi,
Mohamed Riyaz,
ElHamamy Mahmoud M. I.,
Dessouki Amina A.,
Ibrahim Abdelazim,
Ramesh Ganesan
Publication year - 2015
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12433
Subject(s) - nephrotoxicity , cisplatin , pharmacology , kidney , medicine , creatinine , toxicity , renal function , chemotherapy
Summary Cisplatin is a highly effective chemotherapeutic drug used to treat a wide variety of solid tumors. However, its use was limited due its dose‐limiting toxicity to the kidney. Currently, there are no therapies available to treat or prevent cisplatin nephrotoxicity. Honey is a naturally occurring complex liquid and widely used in traditional Ayurvedic medicine to treat many illnesses. However, its effect on cisplatin nephrotoxicity is unknown. To determine the role of honey in cisplatin nephrotoxicity, animals were pretreated orally for a week and then cisplatin was administered. Honey feeding was continued for another 3 days. Our results show that animals with cisplatin‐induced kidney dysfunction, as determined by increased serum creatinine, which received honey feeding had less kidney dysfunction. Improved kidney function was associated with better preservation of kidney morphology in honey‐treated group as compared to the cisplatin alone‐treated group. Interestingly, honey feeding significantly reduced cisplatin‐induced tubular epithelial cell death, immune infiltration into the kidney as well as cytokine and chemokine expression and excretion as compared to cisplatin treated animals. Western blot analysis shows that cisplatin‐induced increase in phosphorylation of NF kB was completely suppressed with honey feeding. In conclusion, honey feeding protects the kidney against cisplatin nephrotoxicity through suppression of inflammation and NF kB activation.