Premium
Serum vitamin D levels are inversely related with non‐alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women
Author(s) -
Lu Zhigang,
Pan Xiaoping,
Hu Yaqin,
Hao Yaping,
Luo Yuqi,
Hu Xiang,
Ma Xiaojing,
Bao Yuqian,
Jia Weiping
Publication year - 2015
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12334
Subject(s) - medicine , fatty liver , gastroenterology , abdominal obesity , interquartile range , obesity , abdominal ultrasonography , vitamin d and neurology , endocrinology , population , disease , metabolic syndrome , surgery , ultrasonography , environmental health
Summary The aim of the present study was to investigate the association between serum vitamin D levels and both visceral adipose and with non‐alcoholic fatty liver disease ( NAFLD ) in Chinese postmenopausal women. Four hundred and fifty‐one postmenopausal women between 45 and 74 years of age (mean (± SD ) age 57.3 ± 4.6 years) were enrolled in the study. All subjects participated in the Shanghai Obesity Study between June and August 2011 and underwent abdominal magnetic resonance imaging and an abdominal ultrasonography. Patients with a visceral fat area ( VFA ) ≥ 80 cm 2 were classified as abdominally obese. Serum 25‐hydroxyvitamin D 3 (25( OH )D 3 ) levels were measured with an electrochemiluminescence immunoassay. The prevalence of NAFLD in the study population was 34.8% ( n = 157). Women with abdominal obesity had significantly lower serum 25( OH )D 3 levels than those without abdominal obesity (median (interquartile range) 11.23 (8.64–14.12) vs 12.56 (9.41–15.98) ng/mL, respectively; P < 0.01). Regardless of abdominal obesity status, serum 25( OH )D 3 levels in patients with NAFLD were lower than those without non‐ NAFLD (11.14 (8.63–13.81) vs 12.92 (9.48–16.37) ng/mL ( P < 0.05) for those without abdominal obesity; 10.86 (8.61–13.56) vs 11.55 (8.82–16.38) ng/mL ( P < 0.05) for those with abdominal obesity). Partial correlation analyses demonstrated a negative correlation between serum 25( OH )D 3 levels and VFA ( P < 0.05). Logistic regression analysis revealed that high serum 25( OH )D 3 levels were a protective factor against NAFLD after adjusting for risk factors such as VFA . In conclusion, independent of visceral obesity, vitamin D is inversely correlated with NAFLD in Chinese postmenopausal women.