Premium
Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats
Author(s) -
Master Jordanna S,
Zimanyi Monika A,
Yin Kom V,
Moritz Karen M,
Gallo Linda A,
Tran Melanie,
Wlodek Mary E,
Black Mary J
Publication year - 2014
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12303
Subject(s) - offspring , left ventricular hypertrophy , muscle hypertrophy , medicine , transgenerational epigenetics , endocrinology , gestation , blood pressure , pregnancy , physiology , biology , genetics
Summary Epidemiological studies have shown an association between low birthweight and adult disease development with transmission to subsequent generations. The aim of the present study was to examine the effect of intrauterine growth restriction in rats, induced by uteroplacental insufficiency, on cardiac structure, number, size, nuclearity, and adult blood pressure in first (F1) and second (F2) generation male offspring. Uteroplacental insufficiency or sham surgery was induced in F0 Wistar‐Kyoto pregnant rats in late gestation giving rise to F1 restricted and control offspring, respectively. F1 control and restricted females were mated with normal males, resulting in F2 control and restricted offspring, respectively. F1 restricted male offspring were significantly lighter at birth ( P < 0.05), but there were no differences in birthweight of F2 offspring. Left ventricular weights and volumes were significantly increased ( P < 0.05) in F1 and F2 restricted offspring at day 35. Left ventricular cardiomyocyte number was not different in F1 and F2 restricted offspring. At 6 months‐of‐age, F1 and F2 restricted offspring had elevated blood pressure (8–15 mmHg, P < 0.05). Our findings demonstrate the emergence of left ventricular hypertrophy and hypertension, with no change in cardiomyocyte number, in F1 restricted male offspring, and this was transmitted to the F2 offspring. The findings support transgenerational programming effects.