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Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs
Author(s) -
Chan Hsiao Chang,
Jiang Xiaohua,
Ruan Ye Chun
Publication year - 2014
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12271
Subject(s) - regulator , cystic fibrosis transmembrane conductance regulator , epigenetics , microrna , biology , microbiology and biotechnology , rna , cystic fibrosis , genetics , gene
Summary Although micro RNA s (mi RNA s) have been recognized as one of the important epigenetic mechanisms that regulate gene expression in response to changes in the environment, the links between environmental cues and changes in mi RNA s remain largely unknown. Localized to the cell membrane and recognized as an anion channel, the cystic fibrosis transmembrane conductance regulator ( CFTR ) has recently been shown to mediate important signalling pathways leading to activation of mi RNA s. This brief review summarizes the related findings and discusses the emerging role of CFTR as an epigenetic regulator, possibly involved in a wide spectrum of physiological and pathological processes.