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Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells
Author(s) -
Han Limin,
Zhao Ganye,
Wang Hui,
Tong Tanjun,
Chen Jun
Publication year - 2014
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12199
Subject(s) - downregulation and upregulation , sirtuin 1 , sirtuin , ubiquitin , calorie restriction , proteasome , microbiology and biotechnology , protein degradation , degradation (telecommunications) , biology , cancer research , chemistry , endocrinology , biochemistry , gene , acetylation , computer science , telecommunications
Summary Sirtuin ( SIRT ) 1 is a key protein in mediating the benefits of calorie restriction ( CR ) in mammals. However, the molecular mechanisms underlying CR ‐induced SIRT 1 upregulation in mammals remain unclear. Herein we show that the elevated SIRT 1 levels are not due to increased SIRT1 mRNA expression. but rather to enhanced SIRT 1 protein stability as a result of reduced ubiquitin‐proteasome degradation of SIRT 1 under limited nutrient conditions. Our observations have important implications for improving healthy aging in humans.