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Pulse pressure variation does not reflect stroke volume variation in mechanically ventilated rats with lipopolysaccharide‐induced pneumonia
Author(s) -
Cherpanath Thomas GV,
Smeding Lonneke,
Lagrand Wim K,
Hirsch Alexander,
Schultz Marcus J,
Groeneveld Johan AB
Publication year - 2014
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12187
Subject(s) - medicine , preload , pulse pressure , ventricle , inferior vena cava , anesthesia , stroke volume , balloon catheter , cardiac output , blood pressure , cardiology , hemodynamics , balloon , heart rate
Summary The present study examined the relationship between centrally measured stroke volume variation ( SVV ) and peripherally derived pulse pressure variation ( PPV ) in the setting of increased total arterial compliance ( C A rt ). Ten male Wistar rats were anaesthetized, paralysed and mechanically ventilated before being randomized to receive intrapulmonary lipopolysaccharide ( LPS ) or no LPS . Pulse pressure ( PP ) was derived from the left carotid artery, whereas stroke volume ( SV ) was measured directly in the left ventricle. Values of SVV and PPV were calculated over three breaths. Balloon inflation of a catheter positioned in the inferior vena cava was used, for a maximum of 30 s, to decrease preload while the SVV and PPV measurements were repeated. Values of C A rt were calculated as SV / PP . Intrapulmonary LPS increased C A rt and SV . Values of SVV and PPV increased in both LPS ‐treated and untreated rats during balloon inflation. There was a correlation between SVV and PPV in untreated rats before ( r = 0.55; P = 0.005) and during ( r = 0.69; P < 0.001) occlusion of the vena cava. There was no such correlation in LPS ‐treated rats either before ( r = −0.08; P = 0.70) or during ( r = 0.36; P = 0.08) vena cava occlusion. In conclusion, under normovolaemic and hypovolaemic conditions, PPV does not reflect SVV during an increase in C A rt following LPS ‐induced pneumonia in mechanically ventilated rats. Our data caution against their interchangeability in human sepsis.