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Regulation of fetal lung development in response to maternal overnutrition
Author(s) -
Lock Mitchell,
McGillick Erin V,
Orgeig Sandra,
McMillen I Caroline,
Morrison Janna L
Publication year - 2013
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12166
Subject(s) - overnutrition , fetus , medicine , in utero , overweight , obesity , pregnancy , lung , diabetes mellitus , respiratory system , obstetrics , physiology , endocrinology , biology , genetics
SummaryWith the worldwide obesity epidemic, the proportion of women entering pregnancy overweight or obese has increased significantly in recent years. Babies born to obese women are at an increased risk of respiratory complications at birth and in childhood. In addition to maternal diabetes, there are a number of metabolic changes that the fetus of an overnourished mother experiences in utero that may modulate lung development and represent the mechanisms underlying the increased risk of respiratory complications. Herein we highlight a series of factors associated with the intrauterine environment of an overnourished mother that may impact on fetal lung development and lead to an increased risk of complications at birth or in postnatal life.