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Reciprocal relationship between plasma ghrelin level and arterial stiffness in hypertensive subjects
Author(s) -
Zhao YinTao,
Yang HaiBo,
Li Ling,
Gao Ke,
Li PengFei,
Xie WeiWei
Publication year - 2013
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12165
Subject(s) - ghrelin , arterial stiffness , medicine , pulse wave velocity , endocrinology , confounding , cardiology , pathophysiology , blood pressure , hormone
Summary Arterial stiffness, considered an independent predictor of cardiovascular morbidity and mortality, is closely associated with hypertension. Futhermore, the role of ghrelin in the development of hypertension has been widely recognized. The purpose of the present study was to explore the potential relationship between circulating ghrelin and arterial stiffness in hypertensive subjects. A total of 192 patients with primary hypertension and 107 normotensive ( NT ) control subjects were enrolled in the present cross‐sectional study. Plasma ghrelin was determined by ELISA . Arterial stiffness was assessed by brachial–ankle pulse wave velocity (ba PWV ) and the augmentation index ( AI x). Both ba PWV and AI x values were markedly higher in the hypertensive compared with NT group ( P < 0.01). In contrast, plasma ghrelin concentrations were significantly lower in hypertensive patients compared with NT subjects ( P < 0.01). Plasma ghrelin concentrations were negatively correlated with age (odds ratio ( OR ) −1.836; P < 0.001), smoking ( OR −1.347; P = 0.042), ba PWV ( OR −1.762; P < 0.001) and AI x ( OR −1.516; P = 0.005), but positively associated with fasting plasma glucose ( OR 1.293; P = 0.047) and HbA1c ( OR 1.413; P = 0.025). The inverse correlation between circulating ghrelin and the extent of arterial stiffness suggests that ghrelin is an independent determinant of arterial stiffness, even after adjustment for confounding cardiovascular risk factors, and it actively participates in the pathophysiology of arterial stiffness in hypertensive subjects.