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Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure
Author(s) -
Ito Daisuke,
Ito Osamu,
Mori Nobuyoshi,
Cao Pengyu,
Suda Chihiro,
Muroya Yoshikazu,
Hao Kiyotaka,
Shimokawa Hiroaki,
Kohzuki Masahiro
Publication year - 2013
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12130
Subject(s) - medicine , nitric oxide synthase , heart failure , endocrinology , ventricle , cardiorenal syndrome , kidney , renal function , endothelial nos , nitric oxide , cardiac function curve , brain natriuretic peptide , enos
Summary There is an interaction between heart and kidney diseases, which is a condition termed cardiorenal syndrome. Exercise training has cardioprotective effects, involving upregulation of endothelial (e) nitric oxide synthase ( NOS ) in the cardiovascular system. However, the effects of exercise training on NOS in the kidney with heart disease are unknown. The aim of the present study was to investigate whether exercise training upregulates NOS in the kidney, left ventricle and aorta of rats with chronic heart failure ( CHF ). M ale S prague‐ D awley rats underwent left coronary artery ligation ( LCAL ) to induce CHF and were randomly assigned to sedentary or treadmill exercise groups 4 weeks after LCAL . Three days after exercising for 4 weeks, urine samples were collected for 24 h and blood samples were collected following decapitation. N itric oxide synthase activity and protein expression were examined. Significant interactions between CHF and exercise training were observed on parameters of cardiac and renal function. Exercise training improved cardiac function, decreased plasma B ‐type natriuretic peptide levels, decreased urinary albumin excretion and increased creatinine clearance in CHF rats. Nitric oxide synthase activity, e NOS expression and neuronal (n) NOS expression were significantly decreased in the left ventricle and kidney of CHF rats. Exercise training significantly increased NOS activity and e NOS and n NOS expression. Upregulation of NOS in the kidney and left ventricle may contribute, in part, to the renal and cardiac protective effects of exercise training in cardiorenal syndrome in CHF rats.