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Store‐operated C a 2+ entry is not required for store refilling in skeletal muscle
Author(s) -
Cully Tanya R,
Launikonis Bradley S
Publication year - 2013
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12078
Subject(s) - skeletal muscle , endoplasmic reticulum , microbiology and biotechnology , chemistry , neuroscience , anatomy , biology
Summary The present review describes store‐operated C a 2+ entry ( SOCE ) in skeletal muscle. Fundamental discoveries in the field of skeletal muscle SOCE are described and the techniques that were used to make these. The advantages and limitations in these techniques are discussed to provide a means of questioning and determining the physiological role(s) of SOCE in skeletal muscle. It is concluded that SOCE has little or no role in the filling of the sarcoplasmic reticulum with C a 2+ at rest or during a single contracture. It is likely that SOCE is activated during fatigue, although direct measurements of SOCE are lacking and the physiological significance remains uncertain.