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Renal function‐dependent association of serum uric acid with metabolic syndrome and hepatic fat content in a middle‐aged and elderly Chinese population
Author(s) -
Xia MingFeng,
Lin HuanDong,
Li XiaoMing,
Yan HongMei,
Bian Hua,
Chang XinXia,
He WanYuan,
Jeekel Johannes,
Hofman Albert,
Gao Xin
Publication year - 2012
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.12011
Subject(s) - renal function , metabolic syndrome , medicine , uric acid , endocrinology , population , gastroenterology , fatty liver , hyperuricemia , physiology , disease , obesity , environmental health
Summary The effect of uric acid ( UA ) on the pathogenesis of metabolic disorders is highly dependent on its physicochemical properties, and hyperuricaemia associated with different conditions may have different clinical meanings. The aim of the present study was to investigate the association of serum UA levels with metabolic syndrome and non‐alcoholic fatty liver disease ( NAFLD ) in a middle‐aged and elderly population with normal and impaired renal function. The cross‐sectional study was performed on 1141 participants (426 men, 715 women; mean age 62 years) enrolled from the Shanghai Changfeng community. Each participant underwent a standard interview, with anthropometric and laboratory measurements. Hepatic fat content ( HFC ) was determined by a newly established quantitative ultrasound method. Univariate correlation analysis showed that serum UA was associated with all components of metabolic syndrome and HFC ( r = 0.193, P < 0.001), especially in participants with a normal estimated glomerular filtration rate (e GFR ; r = 0.255, P < 0.001). Logistic regression analysis demonstrated an independent association of serum UA with metabolic syndrome and NAFLD in participants with normal renal function, but not in those with e GFR < 90 m L /min per 1.73 m 2 . Furthermore, multivariate linear analysis showed that UA levels were independently associated with HFC ( P = 0.003), but only in participants with normal e GFR . Elevated serum UA is independently associated with metabolic syndrome and NAFLD in patients with normal renal excretory function. However, in those with renal insufficiency, hyperuricaemia has no association with metabolic disorders.