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Targeting of neutrophil activation in the early phase of the disease for prevention of Coronavirus disease‐19 severity
Author(s) -
Sendo Fujiro,
Yoshitake Hiroshi,
Araki Yoshihiko
Publication year - 2022
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12978
Subject(s) - disease , immunology , coronavirus , inflammation , acute phase protein , biology , complement system , medicine , covid-19 , immune system , infectious disease (medical specialty)
Abstract The prevention of the disease severity seems critical for reducing the mortality of Coronavirus (CoV) disease‐19. The neutrophils play a key role in the induction of severity. It is proposed here that inhibition of neutrophil activation and/or cascade reactions of complement, leading to this cell activation at the early phase of the disease, is a potential tool to inhibit aggravation of the disease. The need for appropriate timing in intervention is emphasized as follows. (1) Intervention at the very early stage of severe acute respiratory syndrome‐CoV‐2 infection may harm the defensive host response to the infection because of the critical function of neutrophils in this response, and (2) intervention at too late a stage will not stop the infiltration of fully activated neutrophils that produce large amounts of toxic substances.