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Resveratrol ameliorates thymus senescence changes in D‐galactose induced mice
Author(s) -
Wei Tingting,
Li Mengjie,
Guo Li,
Xie Yandong,
Chen Wenhui,
Sun Yun,
Liu Guohong,
Ding Yi,
Chai Yurong
Publication year - 2020
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12833
Subject(s) - biology , senescence , autoimmune regulator , resveratrol , endocrinology , cd8 , medicine , t cell , lymphotoxin , thymic involution , receptor , immunology , immune system , microbiology and biotechnology , tumor necrosis factor alpha , autoimmunity , pharmacology , biochemistry
The thymic microenvironment plays an important role in the development of T cells. A decrease of thymic epithelial cells is the main cause of age‐related thymic atrophy or degeneration. Resveratrol (RSV), a phytoalexin produced from plants, has been shown to inhibit the adverse effects of dietary obesity on the structure and function of the thymus. D‐Galactose (D‐gal) can induce accelerated aging in mice. In the present study, young mice (2 months old) were injected with D‐gal (120 mg/kg/day) for 8 consecutive weeks to construct an accelerated aging model. Compared with normal control mice, the thymus epithelium of the D‐gal treated mice had structural changes, the number of senescent cells increased, the number of CD4+ T cells decreased, and CD8+ T cells increased. After RSV administration by gavage for 6 weeks, it was found that RSV improved the surface phenotypes of D‐gal treated mice, and recovered thymus function by maintaining the ratio of CD4+ to CD8+ cells. It also indicated that RSV enhanced the cell proliferation and inhibited cell senescence. Increased autoimmune regulator (Aire) expression was present in the RSV treated mice. The lymphotoxin‐beta receptor (LTβR) expression also increased. These findings suggested that RSV intake could restore the alterations caused by D‐gal treatment in the thymus via stimulation of Aire expression.