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Meningitis and bacteremia by nonhemolytic Group B Streptococcus strain: A whole genome analysis
Author(s) -
Shimizu Akihiko,
Tsukagoshi Hiroyuki,
Sekizuka Tsuyoshi,
Kuroda Makoto,
Koizumi Aya,
Fujita Masahiro,
Yamada Yoshiyuki,
Saruki Nobuhiro
Publication year - 2020
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12826
Subject(s) - biology , whole genome sequencing , meningitis , group b , bacteremia , streptococcus , genotyping , streptococcus agalactiae , microbiology and biotechnology , frameshift mutation , group a , strain (injury) , genome , mutation , genetics , gene , genotype , bacteria , medicine , pediatrics , anatomy , antibiotics
Abstract Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β‐hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. The patient developed meningitis 3 days after birth. Genotyping was performed and the characteristics of the strain (GCMC97051) identified by whole genome sequence using next generation sequencing. GCMC97051 possesses genetic alterations such as disruption of cylA by IS 1381A insertion and a frameshift mutation in cylE , resulting in a lack of hemolysis. Thus, nonhemolytic GBS can retain the potential to cause invasive infections.