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Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype‐dependent manner
Author(s) -
Lu Yue,
Yang Xiaojie,
Zhang Leiliang
Publication year - 2020
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12784
Subject(s) - biology , ns5a , genotype , virology , hepatitis c virus , domain (mathematical analysis) , virus , computational biology , genetics , hepacivirus , gene , mathematics , mathematical analysis
Previously, it was found that the hepatitis C virus NS5A interacted with ACBD3 in a genotype‐dependent manner. However, the region in NS5A responsible for association with ACBD3 is not clear. Domain I of NS5A was identified as critical for ACBD3 binding. By comparing the differences of amino acids in domain I from different genotypes of NS5A, it was found that key amino acids potentially corresponded to the affinity of the NS5A‐ACBD3 interaction. The findings not only revealed that domain I of NS5A associates with ACBD3 but they also shed mechanistic light on how NS5A is associated with ACBD3 in a genotype‐dependent manner.