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Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition
Author(s) -
Tatsuno Ichiro,
Isaka Masanori,
Matsumoto Masakado,
Hasegawa Tadao
Publication year - 2019
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12739
Subject(s) - streptococcus pyogenes , biology , genome , whole genome sequencing , strain (injury) , microbiology and biotechnology , genetics , streptococcus , gene , bacteria , staphylococcus aureus , anatomy
Streptococcus pyogenes is a causative agent of streptococcal toxic shock syndrome (STSS). The complete genome sequence of a S. pyogenes strain 10–85 isolated from a STSS patient was recently announced. In this study, the genome sequence was dissected and it was found that the genomic region around 200 kbp (region A) and the genomic region around 1600 kbp (region B) were replaced by each other in strain 10–85, when compared with those in reference strains SF370 and A20. In order to address whether this replacement is unique to 10–85, we further analyzed 163 emm 1‐type strains. The results indicated that none of the strains isolated before 1990 had the replacement. In contrast, most of the strains isolated at least after 2000 appeared to have the 10–85‐type replacement.