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Structures of a highly variable cell‐wall anchored protein‐encoding the spj gene from ST8/SCC mec IVl community‐associated methicillin‐resistant Staphylococcus aureus (CA‐MRSA/J) isolated from 2003 onwards: An indicator of a strongly invasive pathotype
Author(s) -
Wan TsaiWen,
Teng LeeJene,
Yamamoto Tatsuo
Publication year - 2019
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12684
Subject(s) - staphylococcus aureus , gene , methicillin resistant staphylococcus aureus , biology , escherichia coli , genetics , microbiology and biotechnology , bacteria
The cell wall‐anchored protein‐encoding spj gene on staphylococcal cassette chromosome mec IVl (SCC mec IVl) was found to vary in size because of its 22‐ and 86‐aa repeat domains. The 22‐aa repeats are the more flexible of the two repeats, comprising three 11‐aa units, and were classified into three groups with eleven types. The 11/22‐aa repeats are longer in individuals with bullous impetigo, shorter in those with invasive disease and were absent in a fatal case, this last one having been rapidly diagnosed by PCR. IS 431 ‐flanking pUB110 ( bleO , aadD ) is present on SCC mec IVl at 90%. The bacterial surface has the spj product and a unique surface layer.