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Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract
Author(s) -
Matsuo Kenzo,
Haku Akira,
Bi Beibei,
Takahashi Hiroki,
Kamada Nobuhiko,
Yaguchi Takashi,
Saijo Shinobu,
Yoneyama Mitsutoshi,
Goto Yoshiyuki
Publication year - 2019
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12680
Subject(s) - candida albicans , biology , colonization , microbiology and biotechnology , gastrointestinal tract , commensalism , corpus albicans , transplantation , gut flora , pathogen , pathogenic bacteria , feces , bacteria , colonisation resistance , immunology , medicine , biochemistry , genetics , surgery
Gut microbes symbiotically colonize the gastrointestinal (GI) tract, interacting with each other and their host to maintain GI tract homeostasis. Recent reports have shown that gut microbes help protect the gut from colonization by pathogenic microbes. Here, we report that commensal microbes prevent colonization of the GI tract by the pathogenic fungus, Candida albicans . Wild‐type specific pathogen‐free (SPF) mice are resistant to C. albicans colonization of the GI tract. However, administering certain antibiotics to SPF mice enables C. albicans colonization. Quantitative kinetics of commensal bacteria are inversely correlated with the number of C. albicans in the gut. Here, we provide further evidence that transplantation of fecal microbiota is effective in preventing Candida colonization of the GI tract. These data demonstrate the importance of commensal bacteria as a barrier for the GI tract surface and highlight the potential clinical applications of commensal bacteria in preventing pathogenic fungal infections.