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Clinical value of enzyme immunoassay that detects rubella‐specific immunoglobulin M immediately after disease onset
Author(s) -
Kurata Takako,
Uchino Kiyoko,
Hotta Chiemi,
Ogura Atsushi,
Miyoshi Tatsuya,
Ogawa Tomoko,
Kanbayashi Daiki,
Tanaka Tomoyuki,
Yumisashi Takahiro,
Komano Jun
Publication year - 2019
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12664
Subject(s) - rubella , titer , immunology , rash , antibody , immunoglobulin m , immunoassay , medicine , rubella virus , biology , immunoglobulin g , virology , measles , vaccination
A total of 300 patients with nucleic acid test‐confirmed rubella, mostly adults, were investigated to determine the clinical value of a rubella‐specific IgM test using an EIA kit. IgM titers increased after rash onset, the median IgM titer being significantly higher 3 days post‐onset than on previous days ( P < 0.0001). Similarly, the IgM‐positive rate at 3 days post‐onset (61.5%) was significantly higher than on previous days ( P < 0.0001). This IgM test against rubella at 3 days or more post‐disease onset provides the clinically relevant information.
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