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IL‐4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes
Author(s) -
Bao Lei,
Chau Cecilia,
Bao Jeremy,
Tsoukas Maria M.,
Chan Lawrence S.
Publication year - 2018
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12650
Subject(s) - microrna , angiogenesis , biology , inflammation , pathogenesis , cancer research , lymphangiogenesis , immunology , atopic dermatitis , apoptosis , microbiology and biotechnology , gene , cancer , metastasis , genetics
IL‐4 plays an important role in the pathogenesis of atopic dermatitis (AD) by dysregulating many key factors at the transcriptional level. In this study, a microRNA array technique and IL‐4 transgenic mice were used to demonstrate that IL‐4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis. Of the 372 common microRNAs examined, 26 and one microRNAs were found to be up‐ and down‐regulated, respectively. MicroRNA‐101‐5p, −122‐5p, −142‐3p, −204‐5p, −335‐3p, −376a‐3p, −378a‐5p, −639 and −9‐5p are among the most significantly up‐regulated microRNAs. MicroRNA‐147a, the only one that was down‐ regulated in the present study, attenuates TLR‐induced inflammatory responses. These dysregulated microRNAs may provide post‐transcriptional regulation of key genes in AD.