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Transcriptional profiles of pulmonary innate immune responses to isogenic antibiotic‐susceptible and multidrug‐resistant Pseudomonas aeruginosa
Author(s) -
Tam Vincent H.,
Pérez Cynthia,
Ledesma Kimberly R.,
Lewis Russell E.
Publication year - 2018
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12581
Subject(s) - biology , innate immune system , pseudomonas aeruginosa , virulence , microbiology and biotechnology , immune system , multiple drug resistance , antibiotics , gene , bacteria , immunology , genetics
The virulence of an isogenic pair of Pseudomonas aeruginosa strains was studied under similar experimental conditions in two animal infection models. The time to death was significantly longer for the multidrug resistant (MDR) than the wild‐type strain. The transcriptional profiles of 84 innate immune response genes in the lungs of immune competent Balb/C mice were further compared. Significantly weaker expression of genes involved in production of soluble pattern recognition receptor and complement were observed in animals infected with the MDR strain. Altered patterns of innate immune system activation may explain the attenuated virulence in MDR bacteria.