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MASTDISCS combi Carba plus , a simple method for discriminating carbapenemase‐producing Enterobacteriaceae , including OXA‐48‐type producers
Author(s) -
Ohsaki Yusuke,
Kubo Ryoichi,
Hobson Jonathan,
Davies Mya,
Osaka Shunsuke,
Hayashi Wataru,
Taniguchi Yui,
Koide Shota,
Nagano Yukiko,
Nagano Noriyuki
Publication year - 2018
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12553
Subject(s) - enterobacteriaceae , biology , enterobacteriaceae infections , microbiology and biotechnology , meropenem , carbapenem resistant enterobacteriaceae , carbapenem , clinical microbiology , escherichia coli , antibiotics , gene , genetics , antibiotic resistance
Accurate and rapid detection of carbapenemases and identification of their types in Enterobacteriaceae are both still major challenges for clinical laboratories in attempting to prevent the intrusion and transmission of carbapenemase‐producing Enterobacteriaceae . This study aimed to evaluate the performance of the MASTDISCS combi Carba plus disc system in identification of different carbapenemase types, including OXA‐48‐type carbapenemase, for which no specific enzyme inhibitors have so far been available. The simple disc system discriminates carbapenemases, including OXA‐48‐types exhibiting low carbapenem minimum inhibitory concentrations, by targeting Enterobacteriaceae isolates with a EUCAST meropenem screening cut‐off of ≥0.25 mg/L.