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Mechanisms of resistance to quinolones in Salmonella Typhimurium from patients with infectious diarrhea
Author(s) -
Yuan Jing,
Guo Wei
Publication year - 2017
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12476
Subject(s) - salmonella , microbiology and biotechnology , biology , quinolone , diarrhea , virology , multiple drug resistance , antibiotic resistance , enterobacteriaceae , drug resistance , bacteria , antibiotics , gene , escherichia coli , medicine , genetics
This study investigated the mechanisms of resistance of 36 quinolone‐resistant Salmonella Typhimurium strains isolated from outpatients with infectious diarrhea in Beijing Tian Tan Hospital between 2013 and 2015. The resistance spectrum of the 36 strains was measured using a broth dilution method. Class 1 integrons harboring the β‐lactamase gene and mutations in quinolone resistance determining regions were also investigated. All 36 quinolone‐resistant Salmonella Typhimurium strains were found to be multidrug‐resistant and the majority of these strains harbored Class 1 integrons. These findings study suggests that strategies for determining resistance spectrums should be implemented with greater urgency.