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New categories designated as healthcare‐associated and community‐associated methicillin‐resistant Staphylococcus pseudintermedius in dogs
Author(s) -
Kasai Tomoko,
Saegusa Sanae,
Shirai Mitsuyuki,
Murakami Masaru,
Kato Yukio
Publication year - 2016
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12401
Subject(s) - staphylococcus pseudintermedius , sccmec , biology , genotype , microbiology and biotechnology , antimicrobial , meticillin , micrococcaceae , staphylococcus aureus , clone (java method) , veterinary medicine , antibacterial agent , methicillin resistant staphylococcus aureus , staphylococcus , antibiotics , genetics , medicine , bacteria , gene
The incidence of MRSP has been increasing, and treatment options in veterinary medicine are limited. Few previous studies of MRSP have described the relationships between the genotypes, phenotypes, and clinical backgrounds of the isolates. To gain insight into the associations between the microbiological and clinical characteristics of MRSP, we analyzed 282 Staphylococcus pseudintermedius isolates from dogs. A total of 195 (69.1%) strains were identified as mecA ‐positive MRSP and were classified into mainly two genotypes: SCC mec types III (II‐III) (52.8%) and V (37.4%). SCC mec type III MRSP strains were significantly correlated with hospital admission and antimicrobial therapy of the dogs, and exhibited a homogeneous genotype similar to sequence type 71‐MRSP, which is a globally endemic clone in dogs. In contrast, SCC mec type V MRSP strains were not highly correlated with hospital admission and antimicrobial therapy and exhibited genotypic and phenotypic heterogeneity. Properties of MRSP strains SCC mec types III and V were similar to those of HA‐ and CA‐MRSA, respectively. Therefore, we designated these isolates carrying SCC mec types III and V as HA‐MRSP and CA‐MRSP, respectively. Discrimination between HA‐ and CA‐MRSP by oxacillin MIC will provide useful information for treatment and infection control measures for canine MRSP infections.