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Differential induction of type I interferons in macaques by wild‐type measles virus alone or with the hemagglutinin protein of the Edmonston vaccine strain
Author(s) -
Van Nguyen Nguyen,
Kato Seiich,
Nagata Kyosuke,
Takeuchi Kaoru
Publication year - 2016
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12392
Subject(s) - virology , measles virus , hemagglutinin (influenza) , biology , measles , wild type , measles vaccine , virus , attenuated vaccine , recombinant dna , paramyxoviridae , mononegavirales , microbiology and biotechnology , vaccination , viral disease , virulence , mutant , gene , biochemistry
Measles vaccines are highly effective and safe; however, the mechanism(s) underlying their attenuation has not been well understood. In this study, type I IFNs (IFN‐α and IFN‐β) induction in macaques infected with measles virus (MV) strains was examined. Type I IFNs were not induced in macaques infected with wild‐type MV. However, IFN‐α was sharply induced in most macaques infected with recombinant wild‐type MV bearing the hemagglutinin (H) protein of the Edmonston vaccine strain. These results indicate that the H protein of MV vaccine strains may have a role in MV attenuation.