Influence of orally administered  Lactobacillus  GG on respiratory immune response in a murine model of diet‐induced obesity | Zendy

Miyazawa Kenji | Zendy; Yoda Kazutoyo | Zendy; Kawase Manabu | Zendy; Harata Gaku | Zendy; He Fang | Zendy

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Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet‐induced obesity

Author(s) -

Miyazawa Kenji,

Yoda Kazutoyo,

Kawase Manabu,

Harata Gaku,

He Fang

Publication year - 2015

Publication title -

microbiology and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.664

H-Index - 70

eISSN - 1348-0421

pISSN - 0385-5600

DOI - 10.1111/1348-0421.12226

Subject(s) - lactobacillus rhamnosus , biology , immune system , receptor , saline , probiotic , immunity , respiratory system , immunology , feces , lactobacillus , microbiology and biotechnology , medicine , endocrinology , bacteria , biochemistry , genetics , anatomy

Mice with diet‐induced obesity were fed with Lactobacillus rhamnosus GG (LGG) suspended in saline or saline alone (control mice). Pulmonary mRNA expression of IFN‐γ; IFN‐α receptor 1; CD247 antigen; killer cell lectin‐like receptor subfamily K, member 1; TNF‐α; IL‐12 receptor β1 and IL‐2 receptor β, and the proportion of Lactobacillales in feces were significantly greater in the LGG group than in the control mice ( P < 0.05 and P < 0.01, respectively). These results suggest that LGG alters the respiratory immunity of obese subjects through having a potent impact on intestinal immunity.

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