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Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet‐induced obesity
Author(s) -
Miyazawa Kenji,
Yoda Kazutoyo,
Kawase Manabu,
Harata Gaku,
He Fang
Publication year - 2015
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12226
Subject(s) - lactobacillus rhamnosus , biology , immune system , receptor , saline , probiotic , immunity , respiratory system , immunology , feces , lactobacillus , microbiology and biotechnology , medicine , endocrinology , bacteria , biochemistry , genetics , anatomy
Mice with diet‐induced obesity were fed with Lactobacillus rhamnosus GG (LGG) suspended in saline or saline alone (control mice). Pulmonary mRNA expression of IFN‐γ; IFN‐α receptor 1; CD247 antigen; killer cell lectin‐like receptor subfamily K, member 1; TNF‐α; IL‐12 receptor β1 and IL‐2 receptor β, and the proportion of Lactobacillales in feces were significantly greater in the LGG group than in the control mice ( P < 0.05 and P < 0.01, respectively). These results suggest that LGG alters the respiratory immunity of obese subjects through having a potent impact on intestinal immunity.