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Association between aggregative adherence fimbriae types including putative new variants and virulence‐related genes and clump formation among aggR ‐positive Escherichia coli strains isolated in Thailand and Japan
Author(s) -
Ito Kenitiro,
Matsushita Shigeru,
Yamazaki Mitsugu,
Moriya Kazuo,
Kurazono Takayuki,
Hiruta Noriaki,
Narimatsu Hiroshi,
Ueno Nobuhiro,
Isobe Junko,
Yatsuyanagi Jun,
Kumagai Norimichi,
Hashimoto Michiko,
Ratchtrachenchai OrnAg
Publication year - 2014
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12173
Subject(s) - enteroaggregative escherichia coli , biology , virulence , fimbria , escherichia coli , gene , toxin , microbiology and biotechnology , genetics , genotype , diarrhea , protein subunit , enterobacteriaceae , medicine
Enteroaggregative Escherichia coli (EAggEC) are an important cause of diarrhea. Four types of AAF have been identified; however, their prevalence and association with virulence properties remain unclear. E. coli strains carrying the aggR gene as EAggEC that were isolated in Japan and Thailand ( n = 90) were examined for AAF subunit genes, two toxin genes ( pet / astA ), and clump formation. The most prevalent AAF gene was hda A (28%), followed by aaf A (20%), agg A (12%), and agg3A (4%), as well as a putative new AAF sequence (25.6%). Retention status of the toxin genes and intensities of clump formation appeared to vary according to the AAF type.