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Brain sections of hippocampus and fimbria area were obtained from 15‐week‐old ZrchI Prnp ‐/‐ mice previously infected with 600 pfu/mouse of EMCV‐B on post‐infection day (DPI) 7. Sections used in the TUNEL method were counterstained with hematoxylin and eosin. CA1 pyramidal cells in the hippocampus of Rikn Prnp ‐/‐ mice showed apoptosis. A brain section from Rikn Prnp ‐/‐ mice shows mild mononuclear round cell infiltration. Modified from Fig. 3 in Nasu‐Nishimura et al. (2008) Arch Virol 153: 1007‐1012 with permission from Springer.
Author(s) -
Onodera Takashi,
Sakudo Akikazu,
Tsubone Hirokazu,
Itohara Shigeyoshi
Publication year - 2014
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12172
Subject(s) - biology , h&e stain , hippocampus , hippocampal formation , microglia , microbiology and biotechnology , pathology , immunohistochemistry , immunology , medicine , neuroscience , inflammation