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Regulatory B cells correlate with HIV disease progression
Author(s) -
Jiao Yanmei,
Wang Xi,
Zhang Tong,
Lijun Sun,
Wang Rui,
Li Wei,
Ji Yunxia,
Wu Hao,
Liu Cuie
Publication year - 2014
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12171
Subject(s) - regulatory b cells , immunology , biology , cd1d , human immunodeficiency virus (hiv) , disease , nat , interleukin 10 , t cell , medicine , natural killer t cell , immune system , computer network , computer science
A rare subset of IL‐10‐producing B cells, named Breg, was recently identified in mice and humans. Currently, there are no unified cell surface markers to identify Breg, and the relationship between the frequency of Breg and HIV disease progression in chronic HIV infection is unclear. In the present study, we determined whether the cell surface markers of Breg reported for other diseases are suitable for identifying Breg in HIV‐infected patients. In addition, we examined the relationship between Breg and HIV disease progression. We found that Breg frequency correlated positively with viral load and negatively with CD4 count in chronic HIV infection. Following antiretroviral treatment, the CD4 count increased and the frequency of Breg decreased stepwise. There was no difference in IL‐10 expression of CD1d hi or CD1d lo cells isolated from HIV‐infected patients. Therefore, CD1d may not be a marker of Breg in HIV‐infected patients.