Premium
Passive immunity with multi‐serotype heat‐killed Shigellae in neonatal mice
Author(s) -
Barman Soumik,
Koley Hemanta,
Nag Dhrubajyoti,
Shinoda Sumio,
Nair Gopinath Balakrish,
Takeda Yoshifumi
Publication year - 2014
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12164
Subject(s) - shigella flexneri , serotype , microbiology and biotechnology , shigella , shigella boydii , biology , shigella dysenteriae , shigella sonnei , immunity , dysentery , lipopolysaccharide , virology , passive immunity , immune system , immunology , salmonella , bacteria , escherichia coli , biochemistry , genetics , gene
The short‐ and long‐term passive protective efficacy of a mixture of heat‐killed cells of six serogroups/serotypes of Shigella strains ( Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei ) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short‐ and long‐term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.