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MHC class I molecules are incorporated into human herpesvirus‐6 viral particles and released into the extracellular environment
Author(s) -
Ota Megumi,
Serada Satoshi,
Naka Tetsuji,
Mori Yasuko
Publication year - 2014
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12121
Subject(s) - extracellular , biology , mhc class i , intracellular , major histocompatibility complex , microbiology and biotechnology , subfamily , mhc restriction , human herpesvirus , mhc class ii , virology , virus , genetics , immune system , gene
ABSTRACT Human herpesvirus‐6 (HHV‐6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV‐6 viral particles and released into the extracellular environment. In addition, HHV‐6A/B‐infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV‐6 infection, causing MHC class I molecules to be transported to virion assembly sites.